Dr. Marco Paret, Université Populaire Balkan, Anneville Institute for Neuro-Somatic Research

Abstract

Recent evidence in psychoneuroendocrinology and epigenetics suggests that environmental and relational states can regulate gene expression, cellular metabolism, and resilience. Magnetic and Epigenetic Therapy (MET) is proposed as a non-verbal, somato-energetic approach integrating Mesmeric techniques, Polyvagal regulation, and cellular epigenetic modulation. MET hypothesizes that coherent magnetic fields generated through focused intention, rhythmic respiration, and interpersonal entrainment may influence the bioelectromagnetic and biochemical milieu of the organism, promoting homeostatic recovery and epigenetic rejuvenation. The approach bridges historical Mesmeric traditions with modern biophysics and epigenetic science, offering a new paradigm of longevity rooted in neuro-somatic coherence.

1. Introduction

The discovery that emotional and autonomic states can shape gene expression has profoundly shifted the understanding of mind–body interaction. Epigenetic modifications—such as DNA methylation, histone acetylation, and non-coding RNA regulation—form a dynamic interface between environmental stimuli and the genome, determining which genes are expressed or silenced.
Parallel to these findings, research in bioelectromagnetism and social neurophysiology indicates that coherence fields—patterns of synchronized physiological oscillations between individuals—can modulate autonomic tone and cellular communication.

Historically, Franz Anton Mesmer and later Baron du Potet described similar principles under the term animal magnetism, proposing that a subtle vital force circulates within living beings and can be harmonized through non-verbal gestures, passes, and focused attention.
Modern neurophysiology, through Polyvagal Theory (Porges, 2011), offers a scientific reinterpretation of these phenomena: the autonomic nervous system can enter states of safety or defense, modulating endocrine, immune, and mitochondrial function.

Magnetic and Epigenetic Therapy aims to synthesize these two domains—Mesmeric coherence and epigenetic plasticity—into a unified framework for non-pharmacological regulation of cellular aging.

2. Theoretical Framework

2.1 The Bio-Energetic Field and Magnetic Coherence

In Mesmeric theory, the body emits and receives subtle electromagnetic patterns—what modern biophysics would call low-frequency biofields.
These fields are measurable today through heart and brain magnetometry (magnetocardiography, magnetoencephalography), showing that coherent states of heart–brain synchronization produce stable electromagnetic signatures correlated with high vagal tone (HRV) and parasympathetic dominance.

When two individuals interact in a state of focused empathy or rhythmic entrainment, their oscillatory patterns may synchronize, creating a shared field.
This process, termed mesmeric coupling, can be considered a bioelectromagnetic feedback loop capable of influencing stress hormones, inflammatory pathways, and potentially epigenetic regulators such as SIRT1, PGC-1α, and NF-κB.

2.2 Epigenetic Modulation through Neuro-Somatic States

The epigenome is responsive to psychosocial and environmental cues. Studies have shown that meditation, yoga, Tai Chi, and breath regulation can induce rapid changes in DNA methylation of genes related to inflammation and oxidative stress (Kaliman et al., 2014; Chaix et al., 2017).
Polyvagal engagement—marked by slow respiration, prosodic rhythm, and relational safety—activates the cholinergic anti-inflammatory pathway, reducing systemic stress signals that would otherwise drive maladaptive epigenetic marks.

Thus, a state of coherent safety functions as a biological switch that maintains or restores youthful gene expression patterns. In this sense, the magnetic rapport of classical mesmerism can be reinterpreted as a state-dependent epigenetic environment that optimizes cellular repair.

3. Mechanisms of Action (Proposed Model)

Level

Physiological Mechanism

Epigenetic Correlate

Mesmeric Analogue

Neural

Polyvagal regulation → ↑ vagal tone, ↓ amygdala activation

Reduced methylation of stress-response genes (e.g. FKBP5, NR3C1)

Calm gaze, magnetic rapport

Endocrine

↓ Cortisol, ↑ DHEA, melatonin

Activation of longevity-related sirtuins (SIRT1, SIRT3)

Fluid passes balancing polarities

Mitochondrial

↑ CoQ10, NAD⁺ turnover, redox homeostasis

Improved PGC-1α signaling, antioxidant gene expression

Transmission of vital energy

Cellular

Microcurrents and electromagnetic entrainment

Modulation of DNA methylation, histone acetylation

Repolarization of vital field

In MET sessions, rhythmic magnetic passes and breath synchronization create a low-frequency oscillatory environment (0.1 Hz range), aligning with the resonance of heart–brain HRV coherence. This frequency domain corresponds to maximal nitric oxide release, endothelial relaxation, and mitochondrial oxygen efficiency—physiological correlates of rejuvenation.

4. Experimental Perspectives

Preliminary pilot studies in progress (Paret et al., 2025) monitor HRV, cortisol, and DNA methylation markers before and after non-verbal sessions combining magnetic passes and coherent breathing.
Expected outcomes include:

• Increased HRV and parasympathetic dominance
  
  

• Reduced methylation of inflammatory genes (IL-6, TNF-α promoters)
  
  

• Upregulation of SIRT1 and mitochondrial biogenesis pathways
  
  

Such findings, if confirmed, would establish the magnetic field of human interaction as an epigenetic environment—a medium capable of influencing the cellular clock of aging.

5. Discussion: From Alchemy to Biology

In alchemical symbolism, the transmutation of base metals into gold represented the refinement of the vital essence (Jing or Mercurius).
From a modern perspective, MET parallels this process: transforming incoherent stress patterns (entropy) into coherent vibrational order (negentropy).
The magnetic passes act as psychobiological rituals guiding the body through the classical alchemical phases—nigredo (purification), albedo (regeneration), rubedo (illumination)—corresponding respectively to stress release, autonomic balance, and epigenetic renewal.

This framework legitimizes the ancient intuition of Saint-Germain and Mesmer as early explorers of what we now describe as bioelectromagnetic and epigenetic self-regulation.

6. Conclusion

Magnetic and Epigenetic Therapy (MET) proposes a synthesis between the measurable and the ineffable:

• scientifically, it acts on the neuro-epigenetic axis through vagal-mitochondrial coherence;
  
  

• energetically, it revives the alchemical art of presence where consciousness reorganizes biology.
  
  

By merging Mesmeric tradition with modern molecular biology, MET offers a contemporary “Western Neidan”—a disciplined practice of inner transmutation that may sustain longevity not as myth, but as physiology refined by awareness.

References (selected)

• Kaliman, P. et al. (2014). Rapid changes in histone deacetylases and inflammatory gene expression after a mindfulness retreat. Psychoneuroendocrinology, 40, 96-107.
  
  

• Chaix, R. et al. (2017). Epigenetic clock analysis of meditators. Psychoneuroendocrinology, 85, 210-214.
  
  

• Porges, S.W. (2011). The Polyvagal Theory. Norton.
  
  

• Sinha, S. et al. (2020). Epigenetic effects of electromagnetic fields on cellular stress pathways. Frontiers in Neuroscience, 14, 894.
  
  

• McCraty, R. (2022). Heart-brain coherence and biofield physiology. Global Advances in Health and Medicine, 11, 1-10.